Publications
(* indicates equal contribution)
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​​Sebastian Palacios*, Euijin Seo*, Yungon Do*, Sohun Lee*, Nayoung Kim, Wonbin Lee, Xiaoyu Chen, Nicholas Guido, Jeong Wook Lee, James J. Collins, "Deep learning enables the design of complex synthetic gene circuits," submitted, 2025.
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Sebastian Palacios, James J. Collins, Domitilla Del Vecchio, "Machine learning for synthetic gene circuit engineering," Current Opinion in Biotechnology, 2025.
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Sebastian Palacios*, Elia Salibi*, Eric Lu, Ron Weiss, Thorsten M. Schlaeger, James J. Collins, Domitilla Del Vecchio, "Reversing transgene silencing via targeted chromatin editing," under review.
Sebastian Palacios*, Simone Bruno*, Ron Weiss, Elia Salibi, Isabella Goodchild-Michelman, Andrew Kane, Katherine Illia and Domitilla Del Vecchio. "Analog epigenetic memory revealed by targeted chromatin editing," Cell Genomics, 2025. MIT News Article. Featured on the front page of MIT's Institute-wide website.
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Huifeng Du*, Simone Bruno*, Kalon J. Overholt*, Sebastian Palacios*, Hsin-Ho Huang, Carlos Barajas, Ben Gross, Cindy Lee, Haley K. Evile, Nuno Rufino de Sousa, Antonio Gigliotti Rothfuchs, and Domitilla Del Vecchio. "A Fieldable Process for Sensitive Detection of Airborne Viruses via Electrophoresis-based RNA Enrichment," submitted, 2024.
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Katherine Illia, Nika Shakiba, Trevor Binham, Ross Jones, Michael Kaminski, Eliezer Aravera, Simone Bruno, Sebastian Palacios, Ron Weiss, James Collins, Domitilla Del Vecchio, Thorsten Schlaeger. "Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts," Science Advances, 2023.
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Alan Cabrera*, Hailey Adelstein*, Fokion Glykofrydis*, Kasey Love*, Sebastian Palacios*, Meng Zhang*, Sarah Lensch, Cara E. Shields, Mark Livingston, Ron Weiss, Huimin Zhao, Karmella A. Haynes, Leonardo Morsut, Yvonne Y. Chen, Ahmad S. Khalil, Wilson Wong, James J. Collins, Susan J. Rosser, Karen Polizzi, Michael Elowitz, Martin Fussenegger, Isaac B. Hilton, Joshua N. Leonard, Lacramioara Bintu, Kate E. Galloway, Tara L. Deans, “The sound of silence: transgene silencing in mammalian cell engineering”, Cell Systems, 2022.
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Sebastian Palacios, Ron Weiss, “An artificial neural network framework for biological circuit engineering in mammalian cells,” In preparation, 2024.
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Breanna DiAndreth, Noreen Wauford, Eileen Hu*, Sebastian Palacios*, Ron Weiss, “PERSIST: A programmable RNA regulation platform using CRISPR endoRNases”, Nature Communications, May 2022.
Onur Aydin*, Austin P. Passaro*, Ritu Raman*, Samantha E. Spellicy, Robert P. Weinberg, Roger Kamm, Matthew Sample, George Truskey, Jeremiah Zartman, Roy Dar, Sebastian Palacios, Jason Wang, Jesse Tordoff, Nuria Montserrat, Rashid Bashir, M. Taher A. Saif1, and Ron Weiss, “Principles for the design of multicellular engineered living systems,” APL Bioengineering, January 2022.
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Artificial neural networks and precision genome engineering frameworks for genetic system engineering in mammalian cells, Massachusetts Institute of Technology, Ph.D. Thesis, 2021.
Edilberto Amorim*, Shirley S. Mo*, Sebastian Palacios*, Mohammad M. Ghassemi, Wei-Hung Weng, Sydney S. Cash, M. Brandon Westover, “Cost-effectiveness analysis of multimodal prognostication in cardiac arrest with EEG monitoring”, Journal of Neurology, August 2020.
Ming-Ru Wu*, Lior Nissim*, Doron Stupp*, Erez Pery, Adina Binder-Nissim, Karen Weisinger, Casper Enghuus, Sebastian Palacios, Melissa Humphrey, Zhizhuo Zhang, Eva Maria Novoa, Manolis Kellis, Ron Weiss, Samuel D Rabkin, Yuval Tabach, Timothy K Lu, “A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)”, Nature Communications, June 2019.
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RNAi-based logic circuitry coupled to Cas9-mediated transcriptional control in human cells and applications to stem cell technology, Massachusetts Institute of Technology, M.S. Thesis, 2017.
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A smart wireless integrated module (SWIM) on organic substrates using inkjet printing technology, Georgia Institute of Technology, M.S. Thesis, 2014.
Sebastian Palacios, Nikhil Ramesh, Symeon Nikolaou, Amin Rida, and Manos M. Tentzeris, “Towards an Implantable Wireless Module with a Bandwidth-enhanced Antenna Manufactured using Inkjet-printing Technology”, Proceedings of the 2013 IEEE International Symposium on Antennas and Propagation and USNC-URSI National Radio Science Conference, Lake Buena Vista, FL, July 2013.
Sebastian Palacios, Amin Rida, Sangkil Kim, Symeon Nikolaou, Samuel Elia and Manos M. Tentzeris, “Towards a Smart Wireless Integrated Module (SWIM) on organic substrates using inkjet printing technology for wireless sensor networks”, Proceedings of the 2012 IEEE International Workshop on Antenna Technology, pp. 20, Tucson, AZ, March 2012.
Sebastian Palacios, Sangkil Kim, Samuel Elia, Amin Rida, Symeon Nikolaou, and Manos M. Tentzeris, “Inkjet-Printed planar antenna for a wireless sensor on paper operating at Wi-Fi frequency”, Proceedings of 2012 IEEE International Symposium on Antennas and Propagation and USNC-URSI National Radio Science Conference, Chicago, IL, July 2012.
Brian Mayton, Gershon Dublon, Sebastian Palacios, Joseph Paradiso, “TRUSS: Tracking Risk Ubiquitously Using Smart Sensing,” Proceedings of the 2012 IEEE Sensors Conference, Taipei, Taiwan, October, 2012.
Benjamin Cook, Taoran Le, Sebastian Palacios, Anya Traille, Manos Tentzeris. “Inkjet-Printed Zero Power Sensors for Large-Scale RFID-Integrated Smart Skins,” Proceedings of the 2013 IEEE International Microwave Symposium, Seattle, WA, June, 2013.
Robert Lipman, Mark Palmer and Sebastian Palacios, “Assessment of conformance and interoperability testing methods used for construction industry product models”, Automation in Construction, Vol. 20, No. 4, pp. 418-428, July 2011